Title |
An investigation of the resolution of inflammation (catabasis) in COPD
|
---|---|
Published in |
Respiratory Research, November 2012
|
DOI | 10.1186/1465-9921-13-101 |
Pubmed ID | |
Authors |
Aina Noguera, Cristina Gomez, Rosa Faner, Borja Cosio, Ana González-Périz, Joan Clària, Angel Carvajal, Alvar Agustí |
Abstract |
Chronic Obstructive Pulmonary Disease (COPD) is characterized by an enhanced inflammatory response to smoking that persists despite quitting. The resolution of inflammation (catabasis) is a complex and highly regulated process where tissue resident macrophages play a key role since they phagocytose apoptotic cells (efferocytosis), preventing their secondary necrosis and the spill-over of their pro-inflammatory cytoplasmic content, and release pro-resolution and tissue repair molecules, such as TGFβ, VEGF and HGF. Because inflammation does not resolve in COPD, we hypothesized that catabasis may be abnormal in these patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 33% |
Argentina | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 3% |
Unknown | 39 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 23% |
Professor > Associate Professor | 5 | 13% |
Student > Master | 4 | 10% |
Student > Bachelor | 3 | 8% |
Student > Ph. D. Student | 3 | 8% |
Other | 9 | 23% |
Unknown | 7 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 30% |
Agricultural and Biological Sciences | 9 | 23% |
Immunology and Microbiology | 5 | 13% |
Biochemistry, Genetics and Molecular Biology | 3 | 8% |
Nursing and Health Professions | 1 | 3% |
Other | 0 | 0% |
Unknown | 10 | 25% |