Title |
The Schistosoma mansoni phylome: using evolutionary genomics to gain insight into a parasite’s biology
|
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Published in |
BMC Genomics, November 2012
|
DOI | 10.1186/1471-2164-13-617 |
Pubmed ID | |
Authors |
Larissa Lopes Silva, Marina Marcet-Houben, Laila Alves Nahum, Adhemar Zerlotini, Toni Gabaldón, Guilherme Oliveira |
Abstract |
Schistosoma mansoni is one of the causative agents of schistosomiasis, a neglected tropical disease that affects about 237 million people worldwide. Despite recent efforts, we still lack a general understanding of the relevant host-parasite interactions, and the possible treatments are limited by the emergence of resistant strains and the absence of a vaccine. The S. mansoni genome was completely sequenced and still under continuous annotation. Nevertheless, more than 45% of the encoded proteins remain without experimental characterization or even functional prediction. To improve our knowledge regarding the biology of this parasite, we conducted a proteome-wide evolutionary analysis to provide a broad view of the S. mansoni's proteome evolution and to improve its functional annotation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Peru | 1 | 50% |
Spain | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 2 | 2% |
United Kingdom | 2 | 2% |
Uruguay | 1 | 1% |
Taiwan | 1 | 1% |
Spain | 1 | 1% |
United States | 1 | 1% |
Unknown | 78 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 19% |
Researcher | 16 | 19% |
Student > Master | 12 | 14% |
Professor | 7 | 8% |
Student > Postgraduate | 6 | 7% |
Other | 16 | 19% |
Unknown | 13 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 39 | 45% |
Biochemistry, Genetics and Molecular Biology | 15 | 17% |
Computer Science | 4 | 5% |
Medicine and Dentistry | 3 | 3% |
Immunology and Microbiology | 3 | 3% |
Other | 10 | 12% |
Unknown | 12 | 14% |