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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Microbiome dynamics of human epidermis following skin barrier disruption
|
|---|---|
| Published in |
Genome Biology, November 2012
|
| DOI | 10.1186/gb-2012-13-11-r101 |
| Pubmed ID | |
| Authors |
Patrick LJM Zeeuwen, Jos Boekhorst, Ellen H van den Bogaard, Heleen D de Koning, Peter MC van de Kerkhof, Delphine M Saulnier, Iris I van Swam, Sacha AFT van Hijum, Michiel Kleerebezem, Joost Schalkwijk, Harro M Timmerman |
| Abstract |
ABSTRACT: BACKGROUND: Recent advances in sequencing technologies have enabled metagenomic analyses of many human body sites. Several studies have catalogued the composition of bacterial communities of the surface of human skin, mostly under static conditions in healthy volunteers. Skin injury will disturb the cutaneous homeostasis of the host tissue and its commensal microbiota, but the dynamics of this process have not been studied before. Here we analyzed the microbiota of the surface layer and the deeper layers of the stratum corneum of normal skin, and we investigated the dynamics of recolonization of skin microbiota following skin barrier disruption by tape stripping as a model of superficial injury. RESULTS: We observed gender differences in microbiota composition and showed that bacteria are not uniformly distributed in the stratum corneum. Phylogenetic distance analysis was employed to follow microbiota development during recolonization of injured skin. Surprisingly, the developing neo-microbiome at day 14 was more similar to that of the deeper stratum corneum layers than to the initial surface microbiome. In addition, we also observed variation in the host response towards superficial injury as assessed by the induction of antimicrobial protein expression in epidermal keratinocytes. CONCLUSIONS: We suggest that the microbiome of the deeper layers, rather than that of the superficial skin layer, may be regarded as the host indigenous microbiome. Characterization of the skin microbiome under dynamic conditions, and the ensuing response of the microbial community and host tissue, will shed further light on the complex interaction between resident bacteria and epidermis. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 43% |
| United Kingdom | 1 | 14% |
| Unknown | 3 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 71% |
| Scientists | 1 | 14% |
| Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 413 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | <1% |
| Germany | 2 | <1% |
| Sweden | 1 | <1% |
| Canada | 1 | <1% |
| Mexico | 1 | <1% |
| Singapore | 1 | <1% |
| Spain | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 401 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 78 | 19% |
| Student > Ph. D. Student | 75 | 18% |
| Student > Master | 51 | 12% |
| Student > Bachelor | 41 | 10% |
| Other | 19 | 5% |
| Other | 64 | 15% |
| Unknown | 85 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 112 | 27% |
| Biochemistry, Genetics and Molecular Biology | 59 | 14% |
| Medicine and Dentistry | 45 | 11% |
| Immunology and Microbiology | 34 | 8% |
| Chemistry | 12 | 3% |
| Other | 52 | 13% |
| Unknown | 99 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2021.
All research outputs
#1,377,724
of 25,374,917 outputs
Outputs from Genome Biology
#1,081
of 4,467 outputs
Outputs of similar age
#8,336
of 192,221 outputs
Outputs of similar age from Genome Biology
#12
of 59 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 192,221 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.