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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Bacillus anthracis S-layer protein BslA binds to extracellular matrix by interacting with laminin
|
|---|---|
| Published in |
BMC Microbiology, August 2016
|
| DOI | 10.1186/s12866-016-0802-8 |
| Pubmed ID | |
| Authors |
Yanchun Wang, Ying Wei, Shengling Yuan, Haoxia Tao, Jie Dong, Zhaoshan Zhang, Wei Tian, Chunjie Liu |
| Abstract |
The Bacillus anthracis S-layer protein, BslA, plays a crucial role in mammalian infection. BslA is required to mediate adherence between host cells and vegetative forms of bacteria and this interaction promotes target organs adherence and blood-brain barrier (BBB) penetration in vivo. This study attempts to identify the potential eukaryotic ligand(s) for B. anthracis BslA protein. Biochemical approaches have indicated that the putative host cell ligand(s) for BslA is a surface protein, which is independent of the sugar components for binding to Bs1A. A ligand screening using blot overlays, far Western blots and mass spectrometry analyses revealed that BslA binds to mammalian laminin. ELISA based solid-phase binding assays and surface plasmon resonance assays demonstrated that there were high affinity interactions between BslA(260-652) and laminin. The SPR results also revealed the dissociation constants values of 3.172 × 10(-9)M for the binding of BslA(260-652) to laminin. These data demonstrated that laminin is a ligand for BslA. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
| Scientists | 1 | 33% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 37% |
| Student > Bachelor | 2 | 11% |
| Professor | 1 | 5% |
| Student > Master | 1 | 5% |
| Researcher | 1 | 5% |
| Other | 2 | 11% |
| Unknown | 5 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 4 | 21% |
| Biochemistry, Genetics and Molecular Biology | 3 | 16% |
| Agricultural and Biological Sciences | 3 | 16% |
| Chemical Engineering | 1 | 5% |
| Business, Management and Accounting | 1 | 5% |
| Other | 2 | 11% |
| Unknown | 5 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2016.
All research outputs
#14,338,684
of 24,093,053 outputs
Outputs from BMC Microbiology
#1,331
of 3,323 outputs
Outputs of similar age
#198,847
of 362,138 outputs
Outputs of similar age from BMC Microbiology
#32
of 88 outputs
Altmetric has tracked 24,093,053 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,323 research outputs from this source. They receive a mean Attention Score of 4.2. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 362,138 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 88 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.