Title |
2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models
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Published in |
BMC Genomics, November 2012
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DOI | 10.1186/1471-2164-13-627 |
Pubmed ID | |
Authors |
Jennifer T Go, Sarah E Belisle, Nicolas Tchitchek, Terrence M Tumpey, Wenjun Ma, Juergen A Richt, David Safronetz, Heinz Feldmann, Michael G Katze |
Abstract |
The 2009 pandemic H1N1 influenza virus emerged in swine and quickly became a major global health threat. In mouse, non human primate, and swine infection models, the pH1N1 virus efficiently replicates in the lung and induces pro-inflammatory host responses; however, whether similar or different cellular pathways were impacted by pH1N1 virus across independent infection models remains to be further defined. To address this we have performed a comparative transcriptomic analysis of acute phase responses to a single pH1N1 influenza virus, A/California/04/2009 (CA04), in the lung of mice, macaques and swine. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
United States | 1 | 2% |
Unknown | 53 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 15 | 27% |
Student > Ph. D. Student | 12 | 22% |
Professor > Associate Professor | 4 | 7% |
Student > Doctoral Student | 4 | 7% |
Student > Master | 4 | 7% |
Other | 8 | 15% |
Unknown | 8 | 15% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 16 | 29% |
Biochemistry, Genetics and Molecular Biology | 11 | 20% |
Medicine and Dentistry | 10 | 18% |
Immunology and Microbiology | 8 | 15% |
Arts and Humanities | 1 | 2% |
Other | 2 | 4% |
Unknown | 7 | 13% |