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Trends in paediatric and adult bloodstream infections at a Ghanaian referral hospital: a retrospective study

Overview of attention for article published in Annals of Clinical Microbiology and Antimicrobials, August 2016
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Title
Trends in paediatric and adult bloodstream infections at a Ghanaian referral hospital: a retrospective study
Published in
Annals of Clinical Microbiology and Antimicrobials, August 2016
DOI 10.1186/s12941-016-0163-z
Pubmed ID
Authors

Noah Obeng-Nkrumah, Appiah-Korang Labi, Naa Okaikor Addison, Juliana Ewuramma Mbiriba Labi, Georgina Awuah-Mensah

Abstract

Bloodstream infections (BSI) are life-threatening emergencies. Identification of the common pathogens and their susceptibility patterns is necessary for timely empirical intervention. We conducted a 4-year retrospective analysis of blood cultures from all patients excluding neonates at the Korle-Bu Teaching hospital, Ghana, from January 2010 through December 2013. Laboratory report data were used to determine BSI, blood culture contamination, pathogen profile, and antimicrobial resistance patterns. Overall, 3633 (23.16 %) out of 15,683 blood cultures were positive for various organisms. Pathogen-positive cultures accounted for 1451 (9.3 %, 95 % CI 8.5-9.8 %). Infants recorded the highest true blood culture positivity (20.9 %, n = 226/1083), followed by the elderly (13.3 %, n = 80/601), children (8.9 %, n = 708/8000) and adults (7.2 %, n = 437/6000) (p = 0.001 for Marascuilo's post hoc). Overall occurrence of BSI declined with increasing age-group (p = 0.001) but the type of isolates did not vary with age except for Citrobacter, Escherichia coli, Klebsiella, Salmonella, and Enterococcus species. Gram negative bacteria predominated in our study (59.8 %, n = 867/1451), but the commonest bacterial isolate was Staphylococcus aureus (21.9 %, n = 318/1451)-and this trend run through the various age-groups. From 2010 to 2013, we observed a significant trend of yearly increase in the frequency of BSI caused by cephalosporin-resistant enterobacteria (Chi square for trend, p = 0.001). Meropenem maintained high susceptibility among all Gram-negative organisms ranging from 96 to 100 %. Among Staphylococcus aureus, susceptibility to cloxacillin was 76.6 %. Our study shows a significantly high blood culture positivity in infants as compared to children, adults and the elderly. There was a preponderance of S. aureus and Gram-negative bacteria across all age-groups. Meropenem was the most active antibiotic for Gram-negative bacteria. Cloxacillin remains a very useful anti-staphylococcal agent.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 166 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 166 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 27 16%
Student > Bachelor 25 15%
Student > Ph. D. Student 19 11%
Student > Postgraduate 16 10%
Researcher 14 8%
Other 30 18%
Unknown 35 21%
Readers by discipline Count As %
Medicine and Dentistry 45 27%
Immunology and Microbiology 21 13%
Nursing and Health Professions 16 10%
Agricultural and Biological Sciences 13 8%
Biochemistry, Genetics and Molecular Biology 11 7%
Other 20 12%
Unknown 40 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2016.
All research outputs
#19,945,185
of 25,374,917 outputs
Outputs from Annals of Clinical Microbiology and Antimicrobials
#445
of 678 outputs
Outputs of similar age
#261,881
of 354,575 outputs
Outputs of similar age from Annals of Clinical Microbiology and Antimicrobials
#14
of 15 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 678 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 354,575 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.