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Increased long noncoding RNA SNHG20 predicts poor prognosis in colorectal cancer

Overview of attention for article published in BMC Cancer, August 2016
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Title
Increased long noncoding RNA SNHG20 predicts poor prognosis in colorectal cancer
Published in
BMC Cancer, August 2016
DOI 10.1186/s12885-016-2719-x
Pubmed ID
Authors

Cong Li, Li Zhou, Jun He, Xue-Qing Fang, Shao-Wen Zhu, Mao-Ming Xiong

Abstract

Long noncoding RNAs (lncRNAs) have been suggested to be involved in the development and progression of malignancies. However, the investigation of small nucleolar RNA host gene 20 (SNHG20) on cancer progression remains unknown. The present study aims to explore the clinical significance of SNHG20 and its potential molecular mechanism in colorectal cancer (CRC). Quantitative real-time PCR (qRT-PCR) was used to measure the SNHG20 expression in a total of 107 CRC tissues and CRC cell lines. Loss of function approach was employed to explore the biological roles of SNHG20 in vitro. Its potential molecular mechanism was further verified by western blotting and qRT-PCR. The results suggested that SNHG20 expression was significantly upregulated in CRC tissues compared to corresponding normal tissues from 107 CRC patients. High expression of SNHG20 was remarkably associated with advanced TNM stage in patients with CRC. Multivariate analyses unraveled that SNHG20 expression was an independent prognostic factor for overall survival in CRC patients. Further functional assays revealed that knockdown of SNHG20 suppressed cell proliferation, invasion and migration, and cell cycle progression in CRC cells. Moreover, SNHG20 regulated cell growth through modulation of a series of cell cycle-associated genes. Our findings suggest that dysregulation of SNHG20 participates in CRC progression and may serve as a potential therapeutic target in CRC patients.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 27%
Researcher 3 20%
Student > Master 2 13%
Other 1 7%
Student > Doctoral Student 1 7%
Other 2 13%
Unknown 2 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 33%
Medicine and Dentistry 4 27%
Agricultural and Biological Sciences 1 7%
Psychology 1 7%
Nursing and Health Professions 1 7%
Other 1 7%
Unknown 2 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2016.
All research outputs
#7,139,977
of 8,255,097 outputs
Outputs from BMC Cancer
#2,811
of 3,474 outputs
Outputs of similar age
#214,211
of 253,888 outputs
Outputs of similar age from BMC Cancer
#179
of 255 outputs
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So far Altmetric has tracked 3,474 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 255 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.