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Novel β-catenin target genes identified in thalamic neurons encode modulators of neuronal excitability

Overview of attention for article published in BMC Genomics, November 2012
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Title
Novel β-catenin target genes identified in thalamic neurons encode modulators of neuronal excitability
Published in
BMC Genomics, November 2012
DOI 10.1186/1471-2164-13-635
Pubmed ID
Authors

Marta B Wisniewska, Andrzej Nagalski, Michal Dabrowski, Katarzyna Misztal, Jacek Kuznicki

Abstract

LEF1/TCF transcription factors and their activator β-catenin are effectors of the canonical Wnt pathway. Although Wnt/β-catenin signaling has been implicated in neurodegenerative and psychiatric disorders, its possible role in the adult brain remains enigmatic. To address this issue, we sought to identify the genetic program activated by β-catenin in neurons. We recently showed that β-catenin accumulates specifically in thalamic neurons where it activates Cacna1g gene expression. In the present study, we combined bioinformatics and experimental approaches to find new β-catenin targets in the adult thalamus.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Germany 1 1%
Korea, Republic of 1 1%
Brazil 1 1%
Unknown 67 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 17%
Student > Master 10 14%
Researcher 9 13%
Student > Bachelor 8 11%
Student > Doctoral Student 4 6%
Other 12 17%
Unknown 16 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 35%
Neuroscience 16 23%
Medicine and Dentistry 6 8%
Biochemistry, Genetics and Molecular Biology 5 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 1%
Other 1 1%
Unknown 17 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2012.
All research outputs
#20,656,161
of 25,374,647 outputs
Outputs from BMC Genomics
#8,709
of 11,244 outputs
Outputs of similar age
#225,164
of 284,360 outputs
Outputs of similar age from BMC Genomics
#155
of 207 outputs
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