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A histone arginine methylation localizes to nucleosomes in satellite II and III DNA sequences in the human genome

Overview of attention for article published in BMC Genomics, November 2012
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Title
A histone arginine methylation localizes to nucleosomes in satellite II and III DNA sequences in the human genome
Published in
BMC Genomics, November 2012
DOI 10.1186/1471-2164-13-630
Pubmed ID
Authors

Daniel Capurso, Hao Xiong, Mark R Segal

Abstract

Applying supervised learning/classification techniques to epigenomic data may reveal properties that differentiate histone modifications. Previous analyses sought to classify nucleosomes containing histone H2A/H4 arginine 3 symmetric dimethylation (H2A/H4R3me2s) or H2A.Z using human CD4+ T-cell chromatin immunoprecipitation sequencing (ChIP-Seq) data. However, these efforts only achieved modest accuracy with limited biological interpretation. Here, we investigate the impact of using appropriate data pre-processing -deduplication, normalization, and position- (peak-) finding to identify stable nucleosome positions - in conjunction with advanced classification algorithms, notably discriminatory motif feature selection and random forests. Performance assessments are based on accuracy and interpretative yield.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Russia 1 3%
Ireland 1 3%
Canada 1 3%
Unknown 26 87%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 33%
Researcher 7 23%
Student > Master 3 10%
Student > Bachelor 2 7%
Other 2 7%
Other 5 17%
Unknown 1 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 43%
Medicine and Dentistry 4 13%
Biochemistry, Genetics and Molecular Biology 4 13%
Computer Science 2 7%
Nursing and Health Professions 1 3%
Other 5 17%
Unknown 1 3%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 November 2012.
All research outputs
#18,320,524
of 22,685,926 outputs
Outputs from BMC Genomics
#8,145
of 10,616 outputs
Outputs of similar age
#136,106
of 178,791 outputs
Outputs of similar age from BMC Genomics
#111
of 146 outputs
Altmetric has tracked 22,685,926 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,616 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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