Title |
A standard numbering scheme for thiamine diphosphate-dependent decarboxylases
|
---|---|
Published in |
BMC Molecular and Cell Biology, November 2012
|
DOI | 10.1186/1471-2091-13-24 |
Pubmed ID | |
Authors |
Constantin Vogel, Michael Widmann, Martina Pohl, Jürgen Pleiss |
Abstract |
Standard numbering schemes for families of homologous proteins allow for the unambiguous identification of functionally and structurally relevant residues, to communicate results on mutations, and to systematically analyse sequence-function relationships in protein families. Standard numbering schemes have been successfully implemented for several protein families, including lactamases and antibodies, whereas a numbering scheme for the structural family of thiamine-diphosphate (ThDP) -dependent decarboxylases, a large subfamily of the class of ThDP-dependent enzymes encompassing pyruvate-, benzoylformate-, 2-oxo acid-, indolpyruvate- and phenylpyruvate decarboxylases, benzaldehyde lyase, acetohydroxyacid synthases and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase (MenD) is still missing.Despite a high structural similarity between the members of the ThDP-dependent decarboxylases, their sequences are diverse and make a pairwise sequence comparison of protein family members difficult. |
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Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
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