Title |
Role of the small GTPase Rab27a during Herpes simplex virus infection of oligodendrocytic cells
|
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Published in |
BMC Microbiology, November 2012
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DOI | 10.1186/1471-2180-12-265 |
Pubmed ID | |
Authors |
Raquel Bello-Morales, Antonio Jesús Crespillo, Alberto Fraile-Ramos, Enrique Tabarés, Antonio Alcina, José Antonio López-Guerrero |
Abstract |
The morphogenesis of herpes simplex virus type 1 (HSV-1) comprises several events, of which some are not completely understood. It has been shown that HSV-1 glycoproteins accumulate in the trans-Golgi network (TGN) and in TGN-derived vesicles. It is also accepted that HSV-1 acquires its final morphology through a secondary envelopment by budding into TGN-derived vesicles coated with viral glycoproteins and tegument proteins. Nevertheless, several aspects of this process remain elusive. The small GTPase Rab27a has been implicated in regulated exocytosis, and it seems to play a key role in certain membrane trafficking events. Rab27a also seems to be required for human cytomegalovirus assembly. However, despite the involvement of various Rab GTPases in HSV-1 envelopment, there is, to date, no data reported on the role of Rab27a in HSV-1 infection. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 67% |
Spain | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 43 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 8 | 19% |
Student > Ph. D. Student | 8 | 19% |
Student > Master | 6 | 14% |
Researcher | 4 | 9% |
Student > Doctoral Student | 3 | 7% |
Other | 2 | 5% |
Unknown | 12 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 23% |
Biochemistry, Genetics and Molecular Biology | 9 | 21% |
Immunology and Microbiology | 5 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Nursing and Health Professions | 1 | 2% |
Other | 4 | 9% |
Unknown | 13 | 30% |