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Combining HLA-DRB1-DQB1 and Mycobacterium Avium Subspecies Paratubercolosis (MAP) antibodies in Sardinian multiple sclerosis patients: associated or independent risk factors?

Overview of attention for article published in BMC Neurology, August 2016
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Title
Combining HLA-DRB1-DQB1 and Mycobacterium Avium Subspecies Paratubercolosis (MAP) antibodies in Sardinian multiple sclerosis patients: associated or independent risk factors?
Published in
BMC Neurology, August 2016
DOI 10.1186/s12883-016-0669-1
Pubmed ID
Authors

J. Frau, D. Cossu, C. Sardu, G. Mameli, G. Coghe, L. Lorefice, G. Fenu, S. Tranquilli, L. A. Sechi, M. G. Marrosu, E. Cocco

Abstract

Amongst Sardinians the human leukocyte antigen (HLA) DRB1-DQB1 haplotypes *15:02-*06:01, *16:01-*05:02, *14:01-4-*05:03 are protective for multiple sclerosis (MS), while *13:03-*03:01, *04:05-*03:01, *03:01-*02:01, *15:01-*06:02 and Mycobacterium avium subspecies paratubercolosis (MAP) are predisposing factors. We studied the correlation between MAP and HLA. Five hundred thirty-one patients were searched for anti-MAP2694 antibodies, DRB1-DQB1 genotyping was performed. The haplotypes were classified as predisposing, neutral or protective. Anti-MAP2694 were found in 23 % of subjects carrying one protective HLA versus 32 % without (p = 0.04). We showed a lower frequency of Abs in patients with protective HLA. These haplotypes could have a protective role for both MS and MAP.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 39%
Other 2 11%
Student > Ph. D. Student 2 11%
Student > Doctoral Student 1 6%
Student > Bachelor 1 6%
Other 2 11%
Unknown 3 17%
Readers by discipline Count As %
Medicine and Dentistry 7 39%
Neuroscience 5 28%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Immunology and Microbiology 1 6%
Unknown 4 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2016.
All research outputs
#18,467,727
of 22,883,326 outputs
Outputs from BMC Neurology
#1,889
of 2,440 outputs
Outputs of similar age
#262,602
of 342,845 outputs
Outputs of similar age from BMC Neurology
#65
of 75 outputs
Altmetric has tracked 22,883,326 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
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