Title |
Mutation patterns of mtDNA: Empirical inferences for the coding region
|
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Published in |
BMC Ecology and Evolution, June 2008
|
DOI | 10.1186/1471-2148-8-167 |
Pubmed ID | |
Authors |
Cristina Santos, Rafael Montiel, Adriana Arruda, Luis Alvarez, Maria Pilar Aluja, Manuela Lima |
Abstract |
Human mitochondrial DNA (mtDNA) has been extensively used in population and evolutionary genetics studies. Thus, a valid estimate of human mtDNA evolutionary rate is important in many research fields. The small number of estimations performed for the coding region of the molecule, showed important differences between phylogenetic and empirical approaches. We analyzed a portion of the coding region of mtDNA (tRNALeu, ND1 and tRNAIle genes), using individuals belonging to extended families from the Azores Islands (Portugal) with the main aim of providing empirical estimations of the mutation rate of the coding region of mtDNA under different assumptions, and hence to better understand the mtDNA evolutionary process. |
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Professor | 5 | 7% |
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Social Sciences | 2 | 3% |
Other | 8 | 12% |
Unknown | 7 | 10% |