Title |
HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients
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Published in |
Infectious Agents and Cancer, August 2016
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DOI | 10.1186/s13027-016-0095-4 |
Pubmed ID | |
Authors |
Bianca Rivera-Peña, Francisco J. Ruíz-Fullana, Germán L. Vélez-Reyes, Rosa J. Rodriguez-Benitez, María J. Marcos-Martínez, Juan Trinidad-Pinedo, Adriana Báez |
Abstract |
HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). HPV-16 has been established as risk factor for OPSCC, but HPV-16 infection may also reside in the larynx and oral cavity. We evaluated HPV-16 status on OS of Head and Neck Squamous Cell Carcinoma (HNSCC) patients. HPV-16 infection was confirmed by amplification of E6 and E7 viral oncogenes through PCR assay and E6 IHC in 185 HNSCC samples. Associations between HPV-16 status and clinicopathological parameters were performed using Fisher's exact test and x(2). Survival analysis was completed using Kaplan-Meier estimator and multivariate Cox regression analysis. OS of HPV-16 positive patients was longer compared to HPV-16 negative patients (P = 0.002). HPV-16 positive tumors of the larynx (LSCC) and pharynx (PSCC) showed improved OS compared to HPV-16 negative tumors. Also, HPV-16 positive patients exposed to radiotherapy presented a better survival. HPV-16 status has a positive prognostic value in HNSCC. Addition of HPV-16 status to the TNM staging can provide better assessment in prognosis and guide treatment for HNSCC patients. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 26% |
Student > Master | 3 | 16% |
Researcher | 3 | 16% |
Student > Doctoral Student | 2 | 11% |
Student > Postgraduate | 2 | 11% |
Other | 2 | 11% |
Unknown | 2 | 11% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 6 | 32% |
Biochemistry, Genetics and Molecular Biology | 5 | 26% |
Immunology and Microbiology | 2 | 11% |
Psychology | 2 | 11% |
Social Sciences | 1 | 5% |
Other | 1 | 5% |
Unknown | 2 | 11% |