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The effects of a selective inhibitor of c-Fos/activator protein-1 on endotoxin-induced acute kidney injury in mice

Overview of attention for article published in BMC Nephrology, November 2012
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Mentioned by

twitter
2 tweeters

Citations

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19 Dimensions

Readers on

mendeley
14 Mendeley
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Title
The effects of a selective inhibitor of c-Fos/activator protein-1 on endotoxin-induced acute kidney injury in mice
Published in
BMC Nephrology, November 2012
DOI 10.1186/1471-2369-13-153
Pubmed ID
Authors

Hiroyuki Miyazaki, Jun Morishita, Masaaki Ueki, Kahoru Nishina, Shunichi Shiozawa, Nobuhiro Maekawa

Abstract

Sepsis has been identified as the most common cause of acute kidney injury (AKI) in intensive care units. Lipopolysaccharide (LPS) induces the production of several proinflammatory cytokines including tumor necrosis factor (TNF)-alpha, a major pathogenetic factor in septic AKI. c-Fos/activator protein (AP)-1 controls the expression of these cytokines by binding directly to AP-1 motifs in the cytokine promoter regions. T-5224 is a new drug developed by computer-aided drug design that selectively inhibits c-Fos/AP-1 binding to DNA. In this study, we tested whether T-5224 has a potential inhibitory effect against LPS-induced AKI, by suppressing the TNF-alpha inflammatory response and other downstream effectors.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 7%
Unknown 13 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 36%
Researcher 3 21%
Student > Bachelor 1 7%
Professor 1 7%
Student > Doctoral Student 1 7%
Other 0 0%
Unknown 3 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 14%
Agricultural and Biological Sciences 2 14%
Neuroscience 2 14%
Medicine and Dentistry 2 14%
Immunology and Microbiology 1 7%
Other 2 14%
Unknown 3 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2012.
All research outputs
#14,349,510
of 21,339,655 outputs
Outputs from BMC Nephrology
#1,346
of 2,327 outputs
Outputs of similar age
#184,254
of 289,940 outputs
Outputs of similar age from BMC Nephrology
#39
of 88 outputs
Altmetric has tracked 21,339,655 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,327 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,940 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 88 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.