Title |
A new treatment for neurogenic inflammation caused by EV71 with CR2-targeted complement inhibitor
|
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Published in |
Virology Journal, November 2012
|
DOI | 10.1186/1743-422x-9-285 |
Pubmed ID | |
Authors |
Shaofu Qiu, Nan Liu, Leili Jia, Guang Yang, Wenli Su, Jing Li, Lixue Song, Chaojie Yang, Jian Wang, Chuanfu Zhang, Zhongqiang Wang, Fei Qiao, Stephen Tomlinson, Carl Atkinson, Yansong Sun, Liuyu Huang, Hongbin Song, Yong Wang, Zhenjun Li |
Abstract |
Enterovirus 71 (EV71), one of the most important neurotropic EVs, has caused death and long-term neurological sequelae in hundreds of thousands of young children in the Asia-Pacific region in the past decade. The neurological diseases are attributed to infection by EV71 inducing an extensive peripheral and central nervous system (CNS) inflammatory response with abnormal cytokine production and lymphocyte depletion induced by EV71 infection. In the absence of specific antiviral agents or vaccines, an effective immunosuppressive strategy would be valuable to alleviate the severity of the local inflammation induced by EV71 infection. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 4% |
Unknown | 27 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 18% |
Student > Postgraduate | 4 | 14% |
Student > Doctoral Student | 3 | 11% |
Researcher | 3 | 11% |
Professor > Associate Professor | 3 | 11% |
Other | 4 | 14% |
Unknown | 6 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 21% |
Immunology and Microbiology | 5 | 18% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Agricultural and Biological Sciences | 2 | 7% |
Chemistry | 2 | 7% |
Other | 3 | 11% |
Unknown | 8 | 29% |