Title |
Protocol of the Cologne Corona Surveillance (CoCoS) Study– a prospective population-based cohort study
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Published in |
BMC Public Health, July 2021
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DOI | 10.1186/s12889-021-11206-9 |
Pubmed ID | |
Authors |
Max Oberste, Lynn-Marie Pusch, Rebecca Roth, Kija Shah-Hosseini, Felix Dewald, Claudia Müller, Luise Stach von Goltzheim, Clara Lehmann, Michael Buess, Anna Wolff, Gerd Fätkenheuer, Gerhard Wiesmüller, Florian Klein, Martin Hellmich, Florian Neuhann |
Abstract |
Surveillance strategies are critical to cope with the current SARS-CoV-2 pandemic and to evaluate, as well as adjust government-imposed countermeasures. Incidence estimates are widely based on laboratory confirmed cases reported by health authorities. Prevalence and incidence data of SARS-CoV-2 is still scarce, along with demographic and behavioural factors associated with infection risk. The Cologne Corona Surveillance Study will be conducted in the City of Cologne, which is the fourth-largest city in Germany with a population of approximately 1.1 million. Researchers will apply self-sampling surveillance to a rolling cohort of Cologne residents. Random samples of 6000 Cologne residents 18 years of age and older will be drawn from the registration office. Upon receiving the information and saliva sample kit, participants will be asked to fill out a questionnaire online or via phone, sign written informed consent, and send back written consent, as well as saliva sample. The saliva samples will be tested for SARS-CoV-2 by reverse PCR. The questionnaire will be administered to gather information about personal characteristics such as health status and risks. A second round of testing will take place 6 weeks after the first. Self-administered saliva sampling proved to be a legitimate and feasible alternative to nasopharyngeal swabs taken by health professionals. However, it is unclear whether the targeted response rate of 40% can be achieved and whether the results are representative of the population. DRKS.de, German Clinical Trials Register (DRKS), Identifier: DRKS00024046 , Registered on 25 February 2021. |
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 13% |
Librarian | 2 | 6% |
Other | 2 | 6% |
Student > Bachelor | 2 | 6% |
Lecturer | 1 | 3% |
Other | 2 | 6% |
Unknown | 18 | 58% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Business, Management and Accounting | 1 | 3% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Psychology | 1 | 3% |
Other | 3 | 10% |
Unknown | 20 | 65% |