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Mendeley readers
Attention Score in Context
| Title |
The regulation of brain states by neuroactive substances distributed via the cerebrospinal fluid; a review
|
|---|---|
| Published in |
Fluids and Barriers of the CNS, January 2010
|
| DOI | 10.1186/1743-8454-7-1 |
| Pubmed ID | |
| Authors |
Jan G Veening, Henk P Barendregt |
| Abstract |
The cerebrospinal fluid (CSF) system provides nutrients to and removes waste products from the brain. Recent findings suggest, however, that in addition, the CSF contains message molecules in the form of actively released neuroactive substances. The concentrations of these vary between locations, suggesting they are important for the changes in brain activity that underlie different brain states, and induce different sensory input and behavioral output relationships.The cranial CSF displays a rapid caudally-directed ventricular flow followed by a slower rostrally-directed subarachnoid flow (mainly towards the cribriform plate and from there into the nasal lymphatics). Thus, many brain areas are exposed to and can be influenced by substances contained in the CSF. In this review we discuss the production and flow of the CSF, including the mechanisms involved in the regulation of its composition. In addition, the available evidence for the release of neuropeptides and other neuroactive substances into the CSF is reviewed, with particular attention to the selective effects of these on distant downstream receptive brain areas. As a conclusion we suggest that (1) the flowing CSF is involved in more than just nutrient and waste control, but is also used as a broadcasting system consisting of coordinated messages to a variety of nearby and distant brain areas; (2) this special form of volume transmission underlies changes in behavioral states. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 177 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 1% |
| United Kingdom | 2 | 1% |
| Brazil | 2 | 1% |
| France | 1 | <1% |
| New Zealand | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 168 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 40 | 23% |
| Student > Ph. D. Student | 27 | 15% |
| Student > Bachelor | 20 | 11% |
| Student > Master | 17 | 10% |
| Student > Doctoral Student | 12 | 7% |
| Other | 36 | 20% |
| Unknown | 25 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 47 | 27% |
| Medicine and Dentistry | 31 | 18% |
| Neuroscience | 30 | 17% |
| Biochemistry, Genetics and Molecular Biology | 10 | 6% |
| Engineering | 9 | 5% |
| Other | 18 | 10% |
| Unknown | 32 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2022.
All research outputs
#15,168,964
of 25,371,288 outputs
Outputs from Fluids and Barriers of the CNS
#245
of 496 outputs
Outputs of similar age
#139,671
of 173,242 outputs
Outputs of similar age from Fluids and Barriers of the CNS
#5
of 6 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 496 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 173,242 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.