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Rare sex or out of reach equilibrium? The dynamics of F IS in partially clonal organisms

Overview of attention for article published in BMC Genetics, June 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

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1 blog

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33 Mendeley
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Title
Rare sex or out of reach equilibrium? The dynamics of F IS in partially clonal organisms
Published in
BMC Genetics, June 2016
DOI 10.1186/s12863-016-0388-z
Pubmed ID
Authors

Katja Reichel, Jean-Pierre Masson, Florent Malrieu, Sophie Arnaud-Haond, Solenn Stoeckel

Abstract

Partially clonal organisms are very common in nature, yet the influence of partial asexuality on the temporal dynamics of genetic diversity remains poorly understood. Mathematical models accounting for clonality predict deviations only for extremely rare sex and only towards mean inbreeding coefficient [Formula: see text]. Yet in partially clonal species, both F IS  < 0 and F IS  > 0 are frequently observed also in populations where there is evidence for a significant amount of sexual reproduction. Here, we studied the joint effects of partial clonality, mutation and genetic drift with a state-and-time discrete Markov chain model to describe the dynamics of F IS over time under increasing rates of clonality. Results of the mathematical model and simulations show that partial clonality slows down the asymptotic convergence to F IS  = 0. Thus, although clonality alone does not lead to departures from Hardy-Weinberg expectations once reached the final equilibrium state, both negative and positive F IS values can arise transiently even at intermediate rates of clonality. More importantly, such "transient" departures from Hardy Weinberg proportions may last long as clonality tunes up the temporal variation of F IS and reduces its rate of change over time, leading to a hyperbolic increase of the maximal time needed to reach the final mean [Formula: see text] value expected at equilibrium. Our results argue for a dynamical interpretation of F IS in clonal populations. Negative values cannot be interpreted as unequivocal evidence for extremely scarce sex but also as intermediate rates of clonality in finite populations. Complementary observations (e.g. frequency distribution of multiloci genotypes, population history) or time series data may help to discriminate between different possible conclusions on the extent of clonality when mean [Formula: see text] values deviating from zero and/or a large variation of F IS over loci are observed.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Guadeloupe 1 3%
Unknown 31 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 27%
Student > Master 6 18%
Student > Doctoral Student 4 12%
Student > Postgraduate 2 6%
Student > Bachelor 2 6%
Other 4 12%
Unknown 6 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 45%
Environmental Science 5 15%
Biochemistry, Genetics and Molecular Biology 4 12%
Medicine and Dentistry 2 6%
Nursing and Health Professions 1 3%
Other 1 3%
Unknown 5 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2016.
All research outputs
#1,599,171
of 8,302,052 outputs
Outputs from BMC Genetics
#108
of 705 outputs
Outputs of similar age
#64,766
of 251,587 outputs
Outputs of similar age from BMC Genetics
#6
of 29 outputs
Altmetric has tracked 8,302,052 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 705 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,587 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.