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Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders

Overview of attention for article published in Genome Biology (Online Edition), August 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

Mentioned by

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32 tweeters
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1 research highlight platform

Citations

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179 Dimensions

Readers on

mendeley
317 Mendeley
citeulike
3 CiteULike
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Title
Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders
Published in
Genome Biology (Online Edition), August 2016
DOI 10.1186/s13059-016-1043-8
Pubmed ID
Authors

Liis Uusküla-Reimand, Huayun Hou, Payman Samavarchi-Tehrani, Matteo Vietri Rudan, Minggao Liang, Alejandra Medina-Rivera, Hisham Mohammed, Dominic Schmidt, Petra Schwalie, Edwin J. Young, Jüri Reimand, Suzana Hadjur, Anne-Claude Gingras, Michael D. Wilson

Abstract

Type II DNA topoisomerases (TOP2) regulate DNA topology by generating transient double stranded breaks during replication and transcription. Topoisomerase II beta (TOP2B) facilitates rapid gene expression and functions at the later stages of development and differentiation. To gain new insight into the genome biology of TOP2B, we used proteomics (BioID), chromatin immunoprecipitation, and high-throughput chromosome conformation capture (Hi-C) to identify novel proximal TOP2B protein interactions and characterize the genomic landscape of TOP2B binding at base pair resolution. Our human TOP2B proximal protein interaction network included members of the cohesin complex and nucleolar proteins associated with rDNA biology. TOP2B associates with DNase I hypersensitivity sites, allele-specific transcription factor (TF) binding, and evolutionarily conserved TF binding sites on the mouse genome. Approximately half of all CTCF/cohesion-bound regions coincided with TOP2B binding. Base pair resolution ChIP-exo mapping of TOP2B, CTCF, and cohesin sites revealed a striking structural ordering of these proteins along the genome relative to the CTCF motif. These ordered TOP2B-CTCF-cohesin sites flank the boundaries of topologically associating domains (TADs) with TOP2B positioned externally and cohesin internally to the domain loop. TOP2B is positioned to solve topological problems at diverse cis-regulatory elements and its occupancy is a highly ordered and prevalent feature of CTCF/cohesin binding sites that flank TADs.

Twitter Demographics

The data shown below were collected from the profiles of 32 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 317 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 <1%
France 2 <1%
United Kingdom 2 <1%
Lithuania 1 <1%
Hungary 1 <1%
Mexico 1 <1%
United States 1 <1%
Unknown 307 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 87 27%
Researcher 54 17%
Student > Master 35 11%
Student > Bachelor 32 10%
Student > Doctoral Student 13 4%
Other 46 15%
Unknown 50 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 138 44%
Agricultural and Biological Sciences 75 24%
Medicine and Dentistry 13 4%
Computer Science 9 3%
Physics and Astronomy 5 2%
Other 22 7%
Unknown 55 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2018.
All research outputs
#1,773,967
of 22,884,315 outputs
Outputs from Genome Biology (Online Edition)
#1,586
of 4,125 outputs
Outputs of similar age
#33,507
of 337,459 outputs
Outputs of similar age from Genome Biology (Online Edition)
#23
of 52 outputs
Altmetric has tracked 22,884,315 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,125 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 337,459 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.