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Association between phthalate exposure and lower handgrip strength in an elderly population: a repeated-measures study

Overview of attention for article published in Environmental Health, August 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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Title
Association between phthalate exposure and lower handgrip strength in an elderly population: a repeated-measures study
Published in
Environmental Health, August 2016
DOI 10.1186/s12940-016-0176-2
Pubmed ID
Authors

Kyoung-Nam Kim, Mee-Ri Lee, Yoon-Hyeong Choi, Hyojung Hwang, Se-Young Oh, ChoongHee Park, Yun-Chul Hong

Abstract

Decreased muscle strength can lead to adverse health outcomes in the elderly. A potential association between phthalate exposure and muscle strength was suggested previously, but has not been investigated directly. We hypothesized that phthalate exposure is associated with lower handgrip strength and that the association is modified by the dietary omega-6 to omega-3 ratio. We analyzed 1,228 participants (≥60 years of age) recruited in Seoul and Asan, Republic of Korea. The study participants were surveyed up to three times between 2012 and 2015. At every survey, we collected urine samples and measured handgrip strength twice for each hand. The associations between urine phthalate metabolite concentrations and handgrip strength were evaluated using linear mixed models. Based on dietary information from 391 individuals who participated in the first survey in Seoul, we evaluated the heterogeneity of the association for those with high and low omega-6 to omega-3 ratios, using 8.81 (the 75th quantile) as a cutoff value. Log-transformed creatinine-adjusted concentrations of mono-(2-ethyl-5-oxohexyl phthalate (MEOHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), and mono-n-butyl phthalate (MnBP) were inversely associated with all measured handgrip strengths (β = -0.69 to -0.42, all p-values < 0.05). Associations between phthalate biomarkers and handgrip strength did not differ by sex. When the dietary subgroup was stratified by the omega-6 to omega-3 ratio, the associations were stronger among participants with high ratios. We found inverse associations between phthalate biomarkers and handgrip strength in the elderly; this association was modified by the dietary omega-6 to omega-3 ratio.

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X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 20%
Student > Master 4 16%
Student > Ph. D. Student 4 16%
Lecturer 2 8%
Student > Doctoral Student 2 8%
Other 4 16%
Unknown 4 16%
Readers by discipline Count As %
Medicine and Dentistry 5 20%
Nursing and Health Professions 3 12%
Environmental Science 3 12%
Biochemistry, Genetics and Molecular Biology 2 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 8%
Other 5 20%
Unknown 5 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2022.
All research outputs
#5,017,498
of 24,641,327 outputs
Outputs from Environmental Health
#691
of 1,565 outputs
Outputs of similar age
#80,466
of 344,363 outputs
Outputs of similar age from Environmental Health
#6
of 20 outputs
Altmetric has tracked 24,641,327 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,565 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.7. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,363 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.