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Intracardiac injection of a capsid-modified Ad5/35 results in decreased heart toxicity when compared to standard Ad5

Overview of attention for article published in Virology Journal, November 2012
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Title
Intracardiac injection of a capsid-modified Ad5/35 results in decreased heart toxicity when compared to standard Ad5
Published in
Virology Journal, November 2012
DOI 10.1186/1743-422x-9-296
Pubmed ID
Authors

Raine Toivonen, Juha Koskenvuo, Mari Merentie, Mirva Söderström, Seppo Ylä-Herttuala, Mikko Savontaus

Abstract

Clinical gene therapy trials for cardiovascular diseases have demonstrated the crucial role of efficient gene delivery and transfection technologies in achieving clinically relevant results. We hypothesized that the use of tropism-modified adenoviruses would improve transduction efficacy and to this end we analyzed the transduction efficiency and toxicity of standard Ad5 and tropism-modified Ad5/35 in combination with ultrasound-guided intramyocardial gene delivery.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 7%
Unknown 13 93%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 36%
Student > Bachelor 2 14%
Student > Doctoral Student 1 7%
Other 1 7%
Student > Ph. D. Student 1 7%
Other 3 21%
Unknown 1 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 43%
Biochemistry, Genetics and Molecular Biology 2 14%
Medicine and Dentistry 2 14%
Immunology and Microbiology 1 7%
Sports and Recreations 1 7%
Other 1 7%
Unknown 1 7%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2012.
All research outputs
#18,321,703
of 22,687,320 outputs
Outputs from Virology Journal
#2,425
of 3,030 outputs
Outputs of similar age
#214,989
of 277,026 outputs
Outputs of similar age from Virology Journal
#76
of 91 outputs
Altmetric has tracked 22,687,320 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,030 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.6. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,026 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 91 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.