Title |
Structure of the type IV secretion system in different strains of Anaplasma phagocytophilum
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Published in |
BMC Genomics, November 2012
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DOI | 10.1186/1471-2164-13-678 |
Pubmed ID | |
Authors |
Basima Al-Khedery, Anna M Lundgren, Snorre Stuen, Erik G Granquist, Ulrike G Munderloh, Curtis M Nelson, A Rick Alleman, Suman M Mahan, Anthony F Barbet |
Abstract |
Anaplasma phagocytophilum is an intracellular organism in the Order Rickettsiales that infects diverse animal species and is causing an emerging disease in humans, dogs and horses. Different strains have very different cell tropisms and virulence. For example, in the U.S., strains have been described that infect ruminants but not dogs or rodents. An intriguing question is how the strains of A. phagocytophilum differ and what different genome loci are involved in cell tropisms and/or virulence. Type IV secretion systems (T4SS) are responsible for translocation of substrates across the cell membrane by mechanisms that require contact with the recipient cell. They are especially important in organisms such as the Rickettsiales which require T4SS to aid colonization and survival within both mammalian and tick vector cells. We determined the structure of the T4SS in 7 strains from the U.S. and Europe and revised the sequence of the repetitive virB6 locus of the human HZ strain. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 5% |
Mexico | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 38 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 26% |
Student > Ph. D. Student | 11 | 26% |
Student > Master | 4 | 10% |
Student > Doctoral Student | 3 | 7% |
Other | 3 | 7% |
Other | 6 | 14% |
Unknown | 4 | 10% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 23 | 55% |
Veterinary Science and Veterinary Medicine | 5 | 12% |
Immunology and Microbiology | 4 | 10% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Environmental Science | 1 | 2% |
Other | 2 | 5% |
Unknown | 5 | 12% |