Title |
On the contributions of topological features to transcriptional regulatory network robustness
|
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Published in |
BMC Bioinformatics, November 2012
|
DOI | 10.1186/1471-2105-13-318 |
Pubmed ID | |
Authors |
Faiyaz Al Zamal, Derek Ruths |
Abstract |
Because biological networks exhibit a high-degree of robustness, a systemic understanding of their architecture and function requires an appraisal of the network design principles that confer robustness. In this project, we conduct a computational study of the contribution of three degree-based topological properties (transcription factor-target ratio, degree distribution, cross-talk suppression) and their combinations on the robustness of transcriptional regulatory networks. We seek to quantify the relative degree of robustness conferred by each property (and combination) and also to determine the extent to which these properties alone can explain the robustness observed in transcriptional networks. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 3 | 5% |
United Kingdom | 2 | 4% |
Brazil | 1 | 2% |
Netherlands | 1 | 2% |
Argentina | 1 | 2% |
Italy | 1 | 2% |
Unknown | 48 | 84% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 16 | 28% |
Professor > Associate Professor | 8 | 14% |
Student > Ph. D. Student | 7 | 12% |
Professor | 5 | 9% |
Student > Master | 5 | 9% |
Other | 12 | 21% |
Unknown | 4 | 7% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 23 | 40% |
Computer Science | 9 | 16% |
Biochemistry, Genetics and Molecular Biology | 7 | 12% |
Engineering | 5 | 9% |
Unspecified | 3 | 5% |
Other | 3 | 5% |
Unknown | 7 | 12% |