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Interplay between the HTLV-2 Tax and APH-2 proteins in the regulation of the AP-1 pathway

Overview of attention for article published in Retrovirology, December 2012
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Title
Interplay between the HTLV-2 Tax and APH-2 proteins in the regulation of the AP-1 pathway
Published in
Retrovirology, December 2012
DOI 10.1186/1742-4690-9-98
Pubmed ID
Authors

Céline Marban, Áine McCabe, Terence N Bukong, William W Hall, Noreen Sheehy

Abstract

In contrast with human T-cell leukemia virus type 1 (HTLV-1) that causes ATL (adult T-cell leukemia), HTLV-2 has not been causally linked to malignant disease. The minus strand of the HTLV genomes encode the regulatory proteins HTLV-1 bZIP factor (HBZ) for HTLV-1 and antisense protein of HTLV-2 (APH-2) for HTLV-2. Unlike the viral proteins Tax1 and Tax2, both HBZ and APH-2 are constitutively expressed in infected cells suggesting that they may play important roles in the pathogenesis of these viruses. To date, very little is known about the function of APH-2 except that it inhibits Tax2-mediated transcription of HTLV-2 genes. In the present study, we investigated the role of APH-2 in basal and Tax2B-mediated activation of the AP-1 pathway.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 8%
Unknown 12 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 38%
Student > Ph. D. Student 2 15%
Student > Bachelor 2 15%
Student > Master 2 15%
Unknown 2 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 31%
Agricultural and Biological Sciences 3 23%
Immunology and Microbiology 1 8%
Medicine and Dentistry 1 8%
Neuroscience 1 8%
Other 1 8%
Unknown 2 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2012.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Retrovirology
#1,213
of 1,273 outputs
Outputs of similar age
#256,145
of 286,162 outputs
Outputs of similar age from Retrovirology
#19
of 25 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,273 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,162 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.