Title |
Interplay between the HTLV-2 Tax and APH-2 proteins in the regulation of the AP-1 pathway
|
---|---|
Published in |
Retrovirology, December 2012
|
DOI | 10.1186/1742-4690-9-98 |
Pubmed ID | |
Authors |
Céline Marban, Áine McCabe, Terence N Bukong, William W Hall, Noreen Sheehy |
Abstract |
In contrast with human T-cell leukemia virus type 1 (HTLV-1) that causes ATL (adult T-cell leukemia), HTLV-2 has not been causally linked to malignant disease. The minus strand of the HTLV genomes encode the regulatory proteins HTLV-1 bZIP factor (HBZ) for HTLV-1 and antisense protein of HTLV-2 (APH-2) for HTLV-2. Unlike the viral proteins Tax1 and Tax2, both HBZ and APH-2 are constitutively expressed in infected cells suggesting that they may play important roles in the pathogenesis of these viruses. To date, very little is known about the function of APH-2 except that it inhibits Tax2-mediated transcription of HTLV-2 genes. In the present study, we investigated the role of APH-2 in basal and Tax2B-mediated activation of the AP-1 pathway. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 8% |
Unknown | 12 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 38% |
Student > Ph. D. Student | 2 | 15% |
Student > Bachelor | 2 | 15% |
Student > Master | 2 | 15% |
Unknown | 2 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 31% |
Agricultural and Biological Sciences | 3 | 23% |
Immunology and Microbiology | 1 | 8% |
Medicine and Dentistry | 1 | 8% |
Neuroscience | 1 | 8% |
Other | 1 | 8% |
Unknown | 2 | 15% |