Title |
Generation and characterization of high affinity human monoclonal antibodies that neutralize staphylococcal enterotoxin B
|
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Published in |
Journal of Immune Based Therapies and Vaccines, December 2010
|
DOI | 10.1186/1476-8518-8-9 |
Pubmed ID | |
Authors |
Brian Drozdowski, Yuhong Zhou, Brad Kline, Jared Spidel, Yin Yin Chan, Earl Albone, Howard Turchin, Qimin Chao, Marianne Henry, Jacqueline Balogach, Eric Routhier, Sina Bavari, Nicholas C Nicolaides, Philip M Sass, Luigi Grasso |
Abstract |
Staphylococcal enterotoxins are considered potential biowarfare agents that can be spread through ingestion or inhalation. Staphylococcal enterotoxin B (SEB) is a widely studied superantigen that can directly stimulate T-cells to release a massive amount of proinflammatory cytokines by bridging the MHC II molecules on an antigen presenting cell (APC) and the Vβ chains of the T-cell receptor (TCR). This potentially can lead to toxic, debilitating and lethal effects. Currently, there are no preventative measures for SEB exposure, only supportive therapies. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Italy | 1 | 4% |
Unknown | 23 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 21% |
Researcher | 5 | 21% |
Other | 3 | 13% |
Professor | 2 | 8% |
Student > Postgraduate | 2 | 8% |
Other | 3 | 13% |
Unknown | 4 | 17% |
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Biochemistry, Genetics and Molecular Biology | 6 | 25% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Linguistics | 1 | 4% |
Veterinary Science and Veterinary Medicine | 1 | 4% |
Other | 4 | 17% |
Unknown | 4 | 17% |