Title |
Comparative injection-site pain and tolerability of subcutaneous serum-free formulation of interferonβ-1a versus subcutaneous interferonβ-1b: results of the randomized, multicenter, Phase IIIb REFORMS study
|
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Published in |
BMC Neurology, December 2012
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DOI | 10.1186/1471-2377-12-154 |
Pubmed ID | |
Authors |
Barry Singer, Daniel Bandari, Mark Cascione, Christopher LaGanke, John Huddlestone, Randy Bennett, Fernando Dangond, REFORMS Study Group |
Abstract |
In patients with relapsing-remitting multiple sclerosis (RRMS), subcutaneous (sc) interferon (IFN)β-1a and IFNβ-1b have been shown to reduce relapse rates. A formulation of IFNβ-1a has been produced without fetal bovine serum and without human serum albumin as an excipient (not currently approved for use in the US). The objectives of this study were to evaluate tolerability, injection-site redness, subject-reported satisfaction with therapy, and clinical safety and efficacy of the serum-free formulation of IFNβ-1a versus IFNβ-1b in IFNβ-treatment-naïve patients with RRMS. The objectives of the extension phase were to evaluate long-term safety and tolerability of IFNβ-1a. |
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Geographical breakdown
Country | Count | As % |
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Egypt | 1 | 50% |
Switzerland | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
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Colombia | 1 | 2% |
Unknown | 65 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 10 | 15% |
Other | 7 | 11% |
Student > Master | 7 | 11% |
Student > Bachelor | 6 | 9% |
Student > Ph. D. Student | 4 | 6% |
Other | 10 | 15% |
Unknown | 22 | 33% |
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Agricultural and Biological Sciences | 3 | 5% |
Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Unspecified | 2 | 3% |
Other | 8 | 12% |
Unknown | 26 | 39% |