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Epidemiological investigation of hemophagocytic lymphohistiocytosis in China

Overview of attention for article published in Orphanet Journal of Rare Diseases, August 2021
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Title
Epidemiological investigation of hemophagocytic lymphohistiocytosis in China
Published in
Orphanet Journal of Rare Diseases, August 2021
DOI 10.1186/s13023-021-01976-1
Pubmed ID
Authors

Shuyan Yao, Yini Wang, Yuan Sun, Li Liu, Rui Zhang, Jianpei Fang, Runming Jin, Jie Yu, Fei Li, Jie Bai, Yun Zeng, Cheng Zhang, Huo Tan, Fan Zhou, Yan Chen, Qiaohua Zhang, Zhao Wang

Abstract

Currently, most research on hemophagocytic lymphohistiocytosis (HLH) have focused on etiology and therapy, leaving few epidemiological reports. The published studies of China are mainly regional investigations. We aimed to present the overall epidemiological status of HLH in China, and provide Chinese data for the international HLH epidemiological investigation. The data of HLH cases in China in 2019 were collected and statistically analyzed. Epstein-Barr virus accounted for 44.01% of the 1445 cases in 31 regions and was the most common cause. Lymphoma-associated HLH patients were more often male (P < 0.05) while rheumatic and immune-associated HLH were more often female (P < 0.001). Primary HLH and Epstein-Barr Virus-associated HLH were predominant in children (P < 0.001) while tumor-associated HLH was predominant in adults. Lymphoma-associated HLH was positively correlated with the age of onset (P < 0.01). The diagnosis rate of 29 areas had a significant correlation with per capita Gross domestic product (P < 0.05). The different distribution of HLH etiology by age and gender contributes to the diagnosis of HLH by clinicians; The suboptimal diagnosis rate in regions with a high incidence of HLH in China is a result of the effect of the local economic level indicating the importance of improving the regional medical level.

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Mendeley readers

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Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Other 2 17%
Unspecified 1 8%
Researcher 1 8%
Student > Master 1 8%
Unknown 7 58%
Readers by discipline Count As %
Unspecified 1 8%
Biochemistry, Genetics and Molecular Biology 1 8%
Nursing and Health Professions 1 8%
Unknown 9 75%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2021.
All research outputs
#20,710,927
of 23,310,485 outputs
Outputs from Orphanet Journal of Rare Diseases
#2,518
of 2,673 outputs
Outputs of similar age
#357,355
of 432,227 outputs
Outputs of similar age from Orphanet Journal of Rare Diseases
#97
of 97 outputs
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