Title |
A computational pipeline for the development of multi-marker bio-signature panels and ensemble classifiers
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Published in |
BMC Bioinformatics, December 2012
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DOI | 10.1186/1471-2105-13-326 |
Pubmed ID | |
Authors |
Oliver P Günther, Virginia Chen, Gabriela Cohen Freue, Robert F Balshaw, Scott J Tebbutt, Zsuzsanna Hollander, Mandeep Takhar, W Robert McMaster, Bruce M McManus, Paul A Keown, Raymond T Ng |
Abstract |
Biomarker panels derived separately from genomic and proteomic data and with a variety of computational methods have demonstrated promising classification performance in various diseases. An open question is how to create effective proteo-genomic panels. The framework of ensemble classifiers has been applied successfully in various analytical domains to combine classifiers so that the performance of the ensemble exceeds the performance of individual classifiers. Using blood-based diagnosis of acute renal allograft rejection as a case study, we address the following question in this paper: Can acute rejection classification performance be improved by combining individual genomic and proteomic classifiers in an ensemble? |
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