Title |
A preliminary study for constructing a bioartificial liver device with induced pluripotent stem cell-derived hepatocytes
|
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Published in |
BioMedical Engineering OnLine, December 2012
|
DOI | 10.1186/1475-925x-11-93 |
Pubmed ID | |
Authors |
Masaya Iwamuro, Hidenori Shiraha, Shuhei Nakaji, Masumi Furutani, Naoya Kobayashi, Akinobu Takaki, Kazuhide Yamamoto |
Abstract |
Bioartificial liver systems, designed to support patients with liver failure, are composed of bioreactors and functional hepatocytes. Immunological rejection of the embedded hepatocytes by the host immune system is a serious concern that crucially degrades the performance of the device. Induced pluripotent stem (iPS) cells are considered a desirable source for bioartificial liver systems, because patient-derived iPS cells are free from immunological rejection. The purpose of this paper was to test the feasibility of a bioartificial liver system with iPS cell-derived hepatocyte-like cells. |
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Demographic breakdown
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Mendeley readers
Geographical breakdown
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Other | 8 | 15% |
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