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Pulmonary haptoglobin (pHp) is part of the surfactant system in the human lung

Overview of attention for article published in Diagnostic Pathology, November 2012
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Title
Pulmonary haptoglobin (pHp) is part of the surfactant system in the human lung
Published in
Diagnostic Pathology, November 2012
DOI 10.1186/1746-1596-7-158
Pubmed ID
Authors

Mahdi Abdullah, Torsten Goldmann

Abstract

Since the existence of pHp was demonstrated, it has been shown that this molecule and its receptor CD163 are regulated by different stimuli. Furthermore, a comparably fast secretion of pHp was described as well as the immuno-stimulatory effects. The intention of this study was to elucidate the role of pHp in the human lungs further. Here we show, by means of confocal microscopy and immune-electron-microscopy, a clear co-localization of pHp with surfactant protein-B in lamellar bodies of alveolar epithelial cells type II. These results are underlined by immunohistochemical stainings in differently fixed human lung tissues, which show pHp in vesicular and released form. The images of the released form resemble the intended position of surfactant in the human alveolus. pHp is secreted by Alveolar epithelial cells type II as previously shown. Moreover, pHp is co-localized with Surfactant protein-B. We conclude that the presented data shows that pHp is a native part of the surfactant system in the human lung.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 14%
Unknown 12 86%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 29%
Researcher 3 21%
Other 2 14%
Librarian 1 7%
Professor > Associate Professor 1 7%
Other 0 0%
Unknown 3 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 21%
Computer Science 2 14%
Nursing and Health Professions 1 7%
Psychology 1 7%
Unknown 7 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2012.
All research outputs
#20,176,348
of 22,689,790 outputs
Outputs from Diagnostic Pathology
#941
of 1,118 outputs
Outputs of similar age
#244,541
of 275,833 outputs
Outputs of similar age from Diagnostic Pathology
#20
of 23 outputs
Altmetric has tracked 22,689,790 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,118 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.