Title |
Clinical relevance of novel Otarine herpesvirus-3 in California sea lions (Zalophus californianus): lymphoma, esophageal ulcers, and strandings
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Published in |
Veterinary Research, December 2012
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DOI | 10.1186/1297-9716-43-85 |
Pubmed ID | |
Authors |
Stephanie Venn-Watson, Celeste Benham, Frances M Gulland, Cynthia R Smith, Judy St Leger, Pam Yochem, Hendrik Nollens, Uriel Blas-Machado, Jeremiah Saliki, Katie Colegrove, James FX Wellehan, Rebecca Rivera |
Abstract |
Herpesviruses have been recognized in marine mammals, but their clinical relevance is not always easy to assess. A novel otarine herpesvirus-3 (OtHV3) was detected in a geriatric California sea lion (Zalophus californianus), and using a newly developed quantitative PCR assay paired with histology, OtHV3 was associated with esophageal ulcers and B cell lymphoblastic lymphoma in this animal. The prevalence and quantities of OtHV3 were then determined among buffy coats from 87 stranded and managed collection sea lions. Stranded sea lions had a higher prevalence of OtHV3 compared to managed collection sea lions (34.9% versus 12.5%; p = 0.04), and among the stranded sea lions, yearlings were most likely to be positive. Future epidemiological studies comparing the presence and viral loads of OtHV3 among a larger population of California sea lions with and without lymphoid neoplasia or esophageal ulcers would help elucidate the relevance of OtHV3-associated pathologies to these groups. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Belgium | 2 | 5% |
Brazil | 1 | 3% |
Unknown | 36 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 9 | 23% |
Researcher | 6 | 15% |
Student > Ph. D. Student | 5 | 13% |
Student > Master | 5 | 13% |
Student > Bachelor | 4 | 10% |
Other | 5 | 13% |
Unknown | 5 | 13% |
Readers by discipline | Count | As % |
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Veterinary Science and Veterinary Medicine | 12 | 31% |
Agricultural and Biological Sciences | 11 | 28% |
Medicine and Dentistry | 4 | 10% |
Environmental Science | 3 | 8% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Other | 2 | 5% |
Unknown | 6 | 15% |