Title |
Overexpression of SERBP1 (Plasminogen activator inhibitor 1 RNA binding protein) in human breast cancer is correlated with favourable prognosis
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Published in |
BMC Cancer, December 2012
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DOI | 10.1186/1471-2407-12-597 |
Pubmed ID | |
Authors |
Nuran Bektas Serce, Andreas Boesl, Irina Klaman, Sonja von Serényi, Erik Noetzel, Michael F Press, Arno Dimmler, Arndt Hartmann, Jalid Sehouli, Ruth Knuechel, Matthias W Beckmann, Peter A Fasching, Edgar Dahl |
Abstract |
Plasminogen activator inhibitor 1 (PAI-1) overexpression is an important prognostic and predictive biomarker in human breast cancer. SERBP1, a protein that is supposed to regulate the stability of PAI-1 mRNA, may play a role in gynaecological cancers as well, since upregulation of SERBP1 was described in ovarian cancer recently. This is the first study to present a systematic characterisation of SERBP1 expression in human breast cancer and normal breast tissue at both the mRNA and the protein level. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 50% |
France | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 2% |
Unknown | 54 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 13 | 24% |
Researcher | 9 | 16% |
Student > Ph. D. Student | 8 | 15% |
Student > Bachelor | 7 | 13% |
Student > Doctoral Student | 6 | 11% |
Other | 2 | 4% |
Unknown | 10 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 16 | 29% |
Biochemistry, Genetics and Molecular Biology | 11 | 20% |
Medicine and Dentistry | 10 | 18% |
Engineering | 3 | 5% |
Business, Management and Accounting | 2 | 4% |
Other | 4 | 7% |
Unknown | 9 | 16% |