Title |
Onset of polyarticular juvenile idiopathic arthritis with both anti-cyclic citrullinated peptide antibodies and rheumatoid factor in a 3-year-old girl
|
---|---|
Published in |
Pediatric Rheumatology, December 2012
|
DOI | 10.1186/1546-0096-10-41 |
Pubmed ID | |
Authors |
Kozo Yasui, Sonoko Sakata, Hideaki Ochi, Shinji Itamura, Kenta Hirai, Mieko Takenaka, Osamu Mitani, Kazunori Ogawa, Kuniaki Iyoda |
Abstract |
This report describes 3 year old girl with the unusual presentation of polyarticular juvenile idiopathic arthritis (JIA) with anti-cyclic citrullinated peptide (anti-CCP) antibodies and a positive rheumatoid factor (RF). She was initially treated with a nonsteroidal anti-inflammatory drug (NSAID; ibuprofen) followed by methotrexate (MTX, 10 mg/m2/week) and prednisolone (0.25 mg/kg/day), but these treatments were ineffective. Administration of tocilizumab, a humanized antihuman interleukin-6 receptor monoclonal antibody, promptly improved her clinical manifestations, and she has been in complete remission (DAS28 <2.6) without bone erosion and/or destruction. Positivity for both antibodies (anti-CCP and RF) can forecast the severity of JIA (radiographic bone destruction). In such cases the administration of biologic remissive therapy may be prudent early in the disease course. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Mauritius | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 5% |
Unknown | 19 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 20% |
Researcher | 3 | 15% |
Other | 2 | 10% |
Student > Master | 2 | 10% |
Student > Ph. D. Student | 2 | 10% |
Other | 3 | 15% |
Unknown | 4 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 45% |
Unspecified | 1 | 5% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Arts and Humanities | 1 | 5% |
Agricultural and Biological Sciences | 1 | 5% |
Other | 3 | 15% |
Unknown | 4 | 20% |