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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Disease activity and cognition in rheumatoid arthritis: an open label pilot study
|
|---|---|
| Published in |
Arthritis Research & Therapy, December 2012
|
| DOI | 10.1186/ar4108 |
| Pubmed ID | |
| Authors |
Graham Raftery, Jiabao He, Ruth Pearce, Daniel Birchall, Julia L Newton, Andrew M Blamire, John D Isaacs |
| Abstract |
ABSTRACT: INTRODUCTION: We hypothesised that fatigue in rheumatoid arthritis (RA) is related to TNF-alpha induced dysregulation of cerebral blood flow. Our objectives were to assess fatigue, cognitive function and cerebral blood flow before and after initiation of anti-TNF treatment. METHODS: In a pilot study, 15 patients initiating treatment with adalimumab were assessed for fatigue using a visual analogue scale (FACIT-F), cognitive function using a panel of psychometric tests and regional cerebral blood flow using MR perfusion imaging. RESULTS: Patients improved clinically after anti-TNF therapy in terms of DAS28 and FACIT-F. Furthermore significant improvements were documented in full scale, verbal and performance IQ following therapy. There was a non-significant trend towards reduced cerebral perfusion in both grey and white matter, and fatigue at 3 months correlated with cerebral blood flow in white (p = 0.014) and grey (p = 0.005) matter. CONCLUSIONS: We demonstrate for the first time a significant improvement in cognitive function following effective treatment of RA. Although we observed minor reductions in cerebral blood flow, and a correlation between cerebral blood flow and fatigue, a larger, controlled study would be required to affirm a causal relationship. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Spain | 1 | 1% |
| Italy | 1 | 1% |
| Unknown | 75 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 15% |
| Researcher | 10 | 13% |
| Other | 7 | 9% |
| Student > Ph. D. Student | 7 | 9% |
| Student > Bachelor | 6 | 8% |
| Other | 16 | 21% |
| Unknown | 20 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 31 | 40% |
| Neuroscience | 5 | 6% |
| Nursing and Health Professions | 4 | 5% |
| Psychology | 4 | 5% |
| Social Sciences | 3 | 4% |
| Other | 8 | 10% |
| Unknown | 23 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2012.
All research outputs
#20,655,488
of 25,371,288 outputs
Outputs from Arthritis Research & Therapy
#2,907
of 3,381 outputs
Outputs of similar age
#226,617
of 286,212 outputs
Outputs of similar age from Arthritis Research & Therapy
#34
of 41 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,212 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.