You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
AID/APOBEC cytosine deaminase induces genome-wide kataegis
|
|---|---|
| Published in |
Biology Direct, December 2012
|
| DOI | 10.1186/1745-6150-7-47 |
| Pubmed ID | |
| Authors |
Artem G Lada, Alok Dhar, Robert J Boissy, Masayuki Hirano, Aleksandr A Rubel, Igor B Rogozin, Youri I Pavlov |
| Abstract |
Clusters of localized hypermutation in human breast cancer genomes, named "kataegis" (from the Greek for thunderstorm), are hypothesized to result from multiple cytosine deaminations catalyzed by AID/APOBEC proteins. However, a direct link between APOBECs and kataegis is still lacking. We have sequenced the genomes of yeast mutants induced in diploids by expression of the gene for PmCDA1, a hypermutagenic deaminase from sea lamprey. Analysis of the distribution of 5,138 induced mutations revealed localized clusters very similar to those found in tumors. Our data provide evidence that unleashed cytosine deaminase activity is an evolutionary conserved, prominent source of genome-wide kataegis events. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Belgium | 2 | 2% |
| Uruguay | 1 | 1% |
| Germany | 1 | 1% |
| Spain | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 86 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 27% |
| Researcher | 23 | 25% |
| Student > Bachelor | 9 | 10% |
| Professor > Associate Professor | 5 | 5% |
| Student > Master | 5 | 5% |
| Other | 8 | 9% |
| Unknown | 17 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 28 | 30% |
| Agricultural and Biological Sciences | 27 | 29% |
| Medicine and Dentistry | 9 | 10% |
| Mathematics | 2 | 2% |
| Immunology and Microbiology | 2 | 2% |
| Other | 5 | 5% |
| Unknown | 19 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 December 2022.
All research outputs
#1,507,054
of 23,332,901 outputs
Outputs from Biology Direct
#50
of 493 outputs
Outputs of similar age
#14,286
of 283,281 outputs
Outputs of similar age from Biology Direct
#3
of 8 outputs
Altmetric has tracked 23,332,901 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 493 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,281 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.