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Mendeley readers
Attention Score in Context
| Title |
Dual functions of Insig proteins in cholesterol homeostasis
|
|---|---|
| Published in |
Lipids in Health and Disease, December 2012
|
| DOI | 10.1186/1476-511x-11-173 |
| Pubmed ID | |
| Authors |
Xiao-Ying Dong, Sheng-Qiu Tang, Jin-Ding Chen |
| Abstract |
The molecular mechanism of how cells maintain cholesterol homeostasis has become clearer for the understanding of complicated association between sterol regulatory element-binding proteins (SREBPs), SREBP cleavage-activating protein (SCAP), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) and Insuin induced-genes (Insigs). The pioneering researches suggested that SREBP activated the transcription of genes encoding HMG-CoA reductase and all of the other enzymes involved in the synthesis of cholesterol and lipids. However, SREBPs can not exert their activities alone, they must form a complex with another protein, SCAP in the endoplasmic reticulum (ER) and translocate to Golgi. Insigs are sensors and mediators that regulate cholesterol homeostasis through binding to SCAP and HMG-CoA reductase in diverse tissues such as adipose tissue and liver, as well as the cultured cells. In this article, we aim to review on the dual functions of Insig protein family in cholesterol homeostasis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| France | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 125 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 18% |
| Student > Bachelor | 19 | 15% |
| Researcher | 18 | 14% |
| Student > Master | 18 | 14% |
| Student > Doctoral Student | 8 | 6% |
| Other | 21 | 16% |
| Unknown | 21 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 52 | 41% |
| Biochemistry, Genetics and Molecular Biology | 27 | 21% |
| Medicine and Dentistry | 9 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Chemistry | 4 | 3% |
| Other | 7 | 5% |
| Unknown | 25 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2019.
All research outputs
#4,150,040
of 22,689,790 outputs
Outputs from Lipids in Health and Disease
#276
of 1,438 outputs
Outputs of similar age
#44,016
of 280,030 outputs
Outputs of similar age from Lipids in Health and Disease
#6
of 18 outputs
Altmetric has tracked 22,689,790 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,438 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,030 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.