Title |
Healthy goats naturally devoid of prion protein
|
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Published in |
Veterinary Research, December 2012
|
DOI | 10.1186/1297-9716-43-87 |
Pubmed ID | |
Authors |
Sylvie L Benestad, Lars Austbø, Michael A Tranulis, Arild Espenes, Ingrid Olsaker |
Abstract |
Prion diseases such as scrapie in small ruminants, bovine spongiform encephalopathy (BSE) in cattle and Creutzfeldt-Jakob disease (CJD) in man, are fatal neurodegenerative disorders. These diseases result from the accumulation of misfolded conformers of the host-encoded prion protein (PrP) in the central nervous system. To date naturally-occurring PrP free animals have not been reported. Here we describe healthy non-transgenic animals, Norwegian Dairy Goats, lacking prion protein due to a nonsense mutation early in the gene. These animals are predicted to be resistant to prion disease and will be valuable for research and for production of prion-free products. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 25% |
United Kingdom | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 59 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 23% |
Researcher | 9 | 15% |
Student > Bachelor | 6 | 10% |
Student > Postgraduate | 5 | 8% |
Student > Master | 5 | 8% |
Other | 10 | 17% |
Unknown | 11 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 13 | 22% |
Agricultural and Biological Sciences | 13 | 22% |
Neuroscience | 8 | 13% |
Veterinary Science and Veterinary Medicine | 6 | 10% |
Immunology and Microbiology | 2 | 3% |
Other | 3 | 5% |
Unknown | 15 | 25% |