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Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesis

Overview of attention for article published in Retrovirology, December 2012
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1 X user

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Title
Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesis
Published in
Retrovirology, December 2012
DOI 10.1186/1742-4690-9-114
Pubmed ID
Authors

Linda Zane, Junichiro Yasunaga, Yu Mitagami, Venkat Yedavalli, Sai-Wen Tang, Chia-Yen Chen, Lee Ratner, Xiongbin Lu, Kuan-Teh Jeang

Abstract

Human T-cell Leukemia Virus type 1 (HTLV-1) infects 20 million individuals world-wide and causes Adult T-cell Leukemia/Lymphoma (ATLL), a highly aggressive T-cell cancer. ATLL is refractory to treatment with conventional chemotherapy and fewer than 10% of afflicted individuals survive more than 5 years after diagnosis. HTLV-1 encodes a viral oncoprotein, Tax, that functions in transforming virus-infected T-cells into leukemic cells. All ATLL cases are believed to have reduced p53 activity although only a minority of ATLLs have genetic mutations in their p53 gene. It has been suggested that p53 function is inactivated by the Tax protein.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 4%
Unknown 24 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 28%
Student > Bachelor 4 16%
Student > Ph. D. Student 4 16%
Student > Postgraduate 2 8%
Researcher 2 8%
Other 2 8%
Unknown 4 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 36%
Immunology and Microbiology 3 12%
Pharmacology, Toxicology and Pharmaceutical Science 2 8%
Agricultural and Biological Sciences 2 8%
Medicine and Dentistry 2 8%
Other 2 8%
Unknown 5 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 December 2012.
All research outputs
#20,176,348
of 22,689,790 outputs
Outputs from Retrovirology
#1,060
of 1,103 outputs
Outputs of similar age
#248,352
of 280,032 outputs
Outputs of similar age from Retrovirology
#14
of 15 outputs
Altmetric has tracked 22,689,790 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,103 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,032 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.