Title |
Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesis
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Published in |
Retrovirology, December 2012
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DOI | 10.1186/1742-4690-9-114 |
Pubmed ID | |
Authors |
Linda Zane, Junichiro Yasunaga, Yu Mitagami, Venkat Yedavalli, Sai-Wen Tang, Chia-Yen Chen, Lee Ratner, Xiongbin Lu, Kuan-Teh Jeang |
Abstract |
Human T-cell Leukemia Virus type 1 (HTLV-1) infects 20 million individuals world-wide and causes Adult T-cell Leukemia/Lymphoma (ATLL), a highly aggressive T-cell cancer. ATLL is refractory to treatment with conventional chemotherapy and fewer than 10% of afflicted individuals survive more than 5 years after diagnosis. HTLV-1 encodes a viral oncoprotein, Tax, that functions in transforming virus-infected T-cells into leukemic cells. All ATLL cases are believed to have reduced p53 activity although only a minority of ATLLs have genetic mutations in their p53 gene. It has been suggested that p53 function is inactivated by the Tax protein. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 4% |
Unknown | 24 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 28% |
Student > Bachelor | 4 | 16% |
Student > Ph. D. Student | 4 | 16% |
Student > Postgraduate | 2 | 8% |
Researcher | 2 | 8% |
Other | 2 | 8% |
Unknown | 4 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 36% |
Immunology and Microbiology | 3 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
Agricultural and Biological Sciences | 2 | 8% |
Medicine and Dentistry | 2 | 8% |
Other | 2 | 8% |
Unknown | 5 | 20% |