Title |
Genomic insights of protein arginine methyltransferase Hmt1 binding reveals novel regulatory functions
|
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Published in |
BMC Genomics, December 2012
|
DOI | 10.1186/1471-2164-13-728 |
Pubmed ID | |
Authors |
Eric J Milliman, Zihua Hu, Michael C Yu |
Abstract |
Protein arginine methylation is a post-translational modification involved in important biological processes such as transcription and RNA processing. This modification is catalyzed by both type I and II protein arginine methyltransferases (PRMTs). One of the most conserved type I PRMTs is PRMT1, the homolog of which is Hmt1 in Saccharomyces cerevisiae. Hmt1 has been shown to play a role in various gene expression steps, such as promoting the dynamics of messenger ribonucleoprotein particle (mRNP) biogenesis, pre-mRNA splicing, and silencing of chromatin. To determine the full extent of Hmt1's involvement during gene expression, we carried out a genome-wide location analysis for Hmt1. |
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