Title |
Cytokine profile, proliferation and phosphorylation of ERK1/2 and Akt in circulating mononuclear cells from individuals during the chronic intestinal phase of Schistosomiasis mansoni infection
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Published in |
BMC Infectious Diseases, December 2012
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DOI | 10.1186/1471-2334-12-380 |
Pubmed ID | |
Authors |
Roberta Oliveira-Prado, Iramaya Rodrigues Caldas, Andréa Teixeira-Carvalho, Marcus Vinicius Andrade, Rafaelle Christine Gomes Fares, Laís Maroni Portugal, Andréa Gazzinelli, Rodrigo Corrêa-Oliveira, José Renan Cunha-Melo |
Abstract |
The immune response to Schistosoma mansoni is characterized by a granulomatous reaction around the parasite eggs that are trapped in the host liver, and this reaction modulates the immune response during the chronic phase of the disease. The typical peripheral blood mononuclear cell (PBMC) response of patients during the chronic intestinal phase of infection is characterized by a decreased response to an S. mansoni soluble egg antigen. To obtain a greater understanding of Schistosoma infections, this study investigated the effects of the soluble egg antigen (SEA) and soluble adult worm antigen (SWAP) of S. mansoni on cellular proliferation, cytokine production, and ERK1/2 and Akt phosphorylation in PBMCs from infected (XTO) and egg-negative (NI) individuals living in the same endemic area. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 4% |
Unknown | 24 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Professor > Associate Professor | 4 | 16% |
Student > Doctoral Student | 3 | 12% |
Student > Bachelor | 3 | 12% |
Student > Master | 3 | 12% |
Researcher | 3 | 12% |
Other | 4 | 16% |
Unknown | 5 | 20% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 28% |
Agricultural and Biological Sciences | 5 | 20% |
Immunology and Microbiology | 3 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Arts and Humanities | 1 | 4% |
Other | 4 | 16% |
Unknown | 4 | 16% |