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Neuroimaging features of C9ORF72 expansion

Overview of attention for article published in Alzheimer's Research & Therapy, January 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

Mentioned by

blogs
1 blog
twitter
2 tweeters

Citations

dimensions_citation
21 Dimensions

Readers on

mendeley
47 Mendeley
citeulike
1 CiteULike
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Title
Neuroimaging features of C9ORF72 expansion
Published in
Alzheimer's Research & Therapy, January 2012
DOI 10.1186/alzrt148
Pubmed ID
Authors

Jennifer S Yokoyama, Howard J Rosen

Abstract

Hexanucleotide expansion intronic to chromosome 9 open reading frame 72 (C9ORF72) has recently been identified as the most common genetic cause of both familial and sporadic amyotrophic lateral sclerosis and of frontotemporal dementia with or without concomitant motor neuron disease. Given the common frequency of this genetic aberration, clinicians seek to identify neuroimaging hallmarks characteristic of C9ORF72-associated disease, both to provide a better understanding of the underlying degenerative patterns associated with this mutation and to enable better identification of patients for genetic screening and diagnosis. A survey of the literature describing C9ORF72 neuroimaging thus far suggests that patients with this mutation may demonstrate symmetric frontal and temporal lobe, insular, and posterior cortical atrophy, although temporal involvement may be less than that seen in other mutations. Some studies have also suggested cerebellar and thalamic involvement in C9ORF72-associated disease. Diffuse cortical atrophy that includes anterior as well as posterior structures and subcortical involvement thus may represent unique features of C9ORF72.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Unknown 45 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 30%
Student > Ph. D. Student 6 13%
Student > Doctoral Student 6 13%
Other 4 9%
Student > Postgraduate 3 6%
Other 8 17%
Unknown 6 13%
Readers by discipline Count As %
Neuroscience 12 26%
Medicine and Dentistry 11 23%
Biochemistry, Genetics and Molecular Biology 4 9%
Agricultural and Biological Sciences 4 9%
Psychology 4 9%
Other 3 6%
Unknown 9 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2013.
All research outputs
#1,484,584
of 12,561,272 outputs
Outputs from Alzheimer's Research & Therapy
#285
of 539 outputs
Outputs of similar age
#32,513
of 255,884 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#10
of 33 outputs
Altmetric has tracked 12,561,272 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 539 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.0. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,884 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.