Title |
Improvement of ovarian response and oocyte quality of aged female by administration of bone morphogenetic protein-6 in a mouse model
|
---|---|
Published in |
Reproductive Biology and Endocrinology, December 2012
|
DOI | 10.1186/1477-7827-10-117 |
Pubmed ID | |
Authors |
Seung S Park, Min J Park, Bo S Joo, Jong K Joo, Jung B Son, Kyu S Lee |
Abstract |
Advancing female age remains a difficult problem in infertility treatment. Ovarian angiogenesis plays an important role in follicular development and the activation of ovarian angiogenesis has been emerged as a new strategy for the improvement of age-related decline of oocyte quality. BMP-6 affect gonadotropin signals in granulosa cells and it promotes normal fertility by enabling appropriate response to LH and normal oocyte quality. BMP-6 has a potential role in regulation of angiogenesis and regulates the expression of inhibitor of DNA-binding proteins (Ids). Ids involved in the control and timing of follicle selection and granulosa cells differentiation. Especially, Id-1 is well-characterized target of BMP-6 signaling. Therefore, this study investigated whether co-administration of BMP-6 during superovulation process improves ovarian response, oocyte quality and expression of Id-1 and vascular endothelial growth factor (VEGF) in the ovary of aged female using a mouse model. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Unspecified | 14 | 44% |
Researcher | 4 | 13% |
Professor > Associate Professor | 3 | 9% |
Student > Doctoral Student | 2 | 6% |
Other | 1 | 3% |
Other | 4 | 13% |
Unknown | 4 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Unspecified | 14 | 44% |
Agricultural and Biological Sciences | 5 | 16% |
Biochemistry, Genetics and Molecular Biology | 4 | 13% |
Medicine and Dentistry | 2 | 6% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Other | 2 | 6% |
Unknown | 4 | 13% |