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Pseudo-plaque reduction neutralization test (PPRNT) for the measurement of neutralizing antibodies to Crimean-Congo hemorrhagic fever virus

Overview of attention for article published in Virology Journal, January 2013
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Title
Pseudo-plaque reduction neutralization test (PPRNT) for the measurement of neutralizing antibodies to Crimean-Congo hemorrhagic fever virus
Published in
Virology Journal, January 2013
DOI 10.1186/1743-422x-10-6
Pubmed ID
Authors

Nurettin Canakoglu, Engin Berber, Mustafa Ertek, Mustafa D Yoruk, Sukru Tonbak, Yusuf Bolat, Munir Aktas, Ahmet Kalkan, Aykut Ozdarendeli

Abstract

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus of the genus Nairovirus family Bunyaviridae, which are enveloped viruses containing tripartite, negative polarity, single-stranded RNA. CCHF is characterized by high case mortality, occurring in Asia, Africa, the Middle East and Europe. Currently, there are no specific treatments or licensed vaccines available for CCHFV. Recently, two research groups have found adult mice with defective interferon responses allowed to lethal CCHFV infection. These mouse models could provide invaluable information for further studies. Efforts to develop a vaccine against CCHFV are being made. To determine the efficacy of vaccine candidates it is important to conduct serological studies that can accurately measure levels of protective antibodies. In the present study, a pseudo-plaque reduction neutralization test (PPRNT) based on enzyme-catalyzed color development of infected cells probed with anti-CCHFV antibodies was used to measure neutralization antibody of CCHFV.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
South Africa 1 2%
Unknown 44 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 26%
Student > Ph. D. Student 5 11%
Professor 4 9%
Professor > Associate Professor 4 9%
Student > Master 4 9%
Other 9 20%
Unknown 8 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 33%
Immunology and Microbiology 6 13%
Medicine and Dentistry 4 9%
Biochemistry, Genetics and Molecular Biology 3 7%
Veterinary Science and Veterinary Medicine 2 4%
Other 4 9%
Unknown 12 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2013.
All research outputs
#15,260,208
of 22,691,736 outputs
Outputs from Virology Journal
#1,938
of 3,030 outputs
Outputs of similar age
#181,486
of 280,814 outputs
Outputs of similar age from Virology Journal
#50
of 86 outputs
Altmetric has tracked 22,691,736 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,030 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.6. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,814 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.