Title |
Evaluation of the efficacy of memantine in the treatment of fibromyalgia: study protocol for a doubled-blind randomized controlled trial with six-month follow-up
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Published in |
Trials, January 2013
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DOI | 10.1186/1745-6215-14-3 |
Pubmed ID | |
Authors |
Bárbara Olivan-Blázquez, Marta Puebla, Bárbara Masluk, Mari-Cruz Pérez-Yus, Raquel Arcega, Eva Andrés, Yolanda López-del-Hoyo, Rosa Magallon, Miquel Roca, Javier Garcia-Campayo |
Abstract |
Fibromyalgia is a prevalent chronic rheumatic disease of great clinical importance. Recent studies have found raised levels of glutamate in the insula, hippocampus and posterior cingulate cortex regions of the brains of fibromyalgia (FM) patients. This finding has led researchers to speculate about the usefulness of glutamate-blocking drugs such as memantine in the treatment of fibromyalgia. The hypothesis of this study is that the administration of memantine will reduce the glutamate levels, and futhermore, will decrease the perceived pain. The aim of this study is to evaluate the efficacy of memantine in the treatment of pain (pain perception). A secondary objective is to evaluate the efficacy of memantine in the treatment of other clinical symptoms of FM, and to evaluate the efficacy of memantine in reducing brain levels of glutamate, and its effects on the central nervous system as a whole. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 50% |
Canada | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 3 | 2% |
Australia | 1 | <1% |
Unknown | 123 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 19 | 15% |
Student > Bachelor | 19 | 15% |
Student > Master | 16 | 13% |
Student > Postgraduate | 11 | 9% |
Other | 8 | 6% |
Other | 33 | 26% |
Unknown | 21 | 17% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 37 | 29% |
Psychology | 21 | 17% |
Nursing and Health Professions | 9 | 7% |
Neuroscience | 8 | 6% |
Agricultural and Biological Sciences | 5 | 4% |
Other | 16 | 13% |
Unknown | 31 | 24% |