Title |
Whole genome HBV deletion profiles and the accumulation of preS deletion mutant during antiviral treatment
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Published in |
BMC Microbiology, December 2012
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DOI | 10.1186/1471-2180-12-307 |
Pubmed ID | |
Authors |
Dake Zhang, Peiling Dong, Ke Zhang, Libin Deng, Christian Bach, Wei Chen, Feifei Li, Ulrike Protzer, Huiguo Ding, Changqing Zeng |
Abstract |
Hepatitis B virus (HBV), because of its error-prone viral polymerase, has a high mutation rate leading to widespread substitutions, deletions, and insertions in the HBV genome. Deletions may significantly change viral biological features complicating the progression of liver diseases. However, the clinical conditions correlating to the accumulation of deleted mutants remain unclear. In this study, we explored HBV deletion patterns and their association with disease status and antiviral treatment by performing whole genome sequencing on samples from 51 hepatitis B patients and by monitoring changes in deletion variants during treatment. Clone sequencing was used to analyze preS regions in another cohort of 52 patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 25% |
Turkey | 1 | 13% |
Colombia | 1 | 13% |
Unknown | 4 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 4% |
Canada | 1 | 2% |
Unknown | 52 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 15 | 27% |
Researcher | 10 | 18% |
Student > Master | 8 | 15% |
Student > Doctoral Student | 2 | 4% |
Other | 2 | 4% |
Other | 6 | 11% |
Unknown | 12 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 22% |
Agricultural and Biological Sciences | 10 | 18% |
Biochemistry, Genetics and Molecular Biology | 9 | 16% |
Immunology and Microbiology | 3 | 5% |
Nursing and Health Professions | 1 | 2% |
Other | 6 | 11% |
Unknown | 14 | 25% |