Title |
A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus
|
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Published in |
Orphanet Journal of Rare Diseases, January 2013
|
DOI | 10.1186/1750-1172-8-2 |
Pubmed ID | |
Authors |
Nicki Tiffin, Adebowale Adeyemo, Ikechi Okpechi |
Abstract |
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with variable clinical presentation frequently affecting the skin, joints, haemopoietic system, kidneys, lungs and central nervous system. It can be life threatening when major organs are involved. The full pathological and genetic mechanisms of this complex disease are yet to be elucidated; although roles have been described for environmental triggers such as sunlight, drugs and chemicals, and infectious agents. Cellular processes such as inefficient clearing of apoptotic DNA fragments and generation of autoantibodies have been implicated in disease progression. A diverse array of disease-associated genes and microRNA regulatory molecules that are dysregulated through polymorphism and copy number variation have also been identified; and an effect of ethnicity on susceptibility has been described. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Saudi Arabia | 1 | 20% |
Mexico | 1 | 20% |
United States | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 60% |
Scientists | 1 | 20% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Denmark | 1 | <1% |
Italy | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 120 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 28 | 23% |
Researcher | 16 | 13% |
Student > Ph. D. Student | 13 | 10% |
Student > Master | 11 | 9% |
Student > Postgraduate | 10 | 8% |
Other | 20 | 16% |
Unknown | 26 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 43 | 35% |
Agricultural and Biological Sciences | 26 | 21% |
Biochemistry, Genetics and Molecular Biology | 18 | 15% |
Immunology and Microbiology | 4 | 3% |
Chemistry | 3 | 2% |
Other | 4 | 3% |
Unknown | 26 | 21% |