Title |
Revisiting the evolution of mouse LINE-1 in the genomic era
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Published in |
Mobile DNA, January 2013
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DOI | 10.1186/1759-8753-4-3 |
Pubmed ID | |
Authors |
Akash Sookdeo, Crystal M Hepp, Marcella A McClure, Stéphane Boissinot |
Abstract |
LINE-1 (L1) is the dominant category of transposable elements in placental mammals. L1 has significantly affected the size and structure of all mammalian genomes and understanding the nature of the interactions between L1 and its mammalian host remains a question of crucial importance in comparative genomics. For this reason, much attention has been dedicated to the evolution of L1. Among the most studied elements is the mouse L1 which has been the subject of a number of studies in the 1980s and 1990s. These seminal studies, performed in the pre-genomic era when only a limited number of L1 sequences were available, have significantly improved our understanding of L1 evolution. Yet, no comprehensive study on the evolution of L1 in mouse has been performed since the completion of this genome sequence. |
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Professor | 10 | 5% |
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