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Response to Grisedale and Van Daal: comparison of STR profiling from low template DNA extracts with and without the consensus profiling method

Overview of attention for article published in Investigative Genetics, January 2013
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Title
Response to Grisedale and Van Daal: comparison of STR profiling from low template DNA extracts with and without the consensus profiling method
Published in
Investigative Genetics, January 2013
DOI 10.1186/2041-2223-4-1
Pubmed ID
Authors

Bas Kokshoorn, Bart J Blankers

Abstract

In a recent contribution to this journal Grisedale and Van Daal concluded that a single STR analysis of all available template DNA is to be preferred over replicate analyses and a consensus approach when analyzing low template DNA samples. A single STR analysis approach does not allow for an assessment of the validity of the resulting DNA profile. We argue that the use of replicate amplifications is the best way to objectively quantify the extent of the stochastic variation in the data. By applying consensus methodology and/or a probabilistic model, the interpretation of the data will therefore be more objective and reliable.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Other 2 18%
Student > Doctoral Student 1 9%
Student > Ph. D. Student 1 9%
Researcher 1 9%
Professor > Associate Professor 1 9%
Other 1 9%
Unknown 4 36%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 27%
Biochemistry, Genetics and Molecular Biology 2 18%
Chemistry 2 18%
Medicine and Dentistry 1 9%
Unknown 3 27%