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Antisense-mediated isoform switching of steroid receptor coactivator-1 in the central nucleus of the amygdala of the mouse brain

Overview of attention for article published in BMC Neuroscience, January 2013
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Title
Antisense-mediated isoform switching of steroid receptor coactivator-1 in the central nucleus of the amygdala of the mouse brain
Published in
BMC Neuroscience, January 2013
DOI 10.1186/1471-2202-14-5
Pubmed ID
Authors

Ioannis Zalachoras, Gwendolynn Grootaers, Lisa TCM van Weert, Yves Aubert, Suzanne R de Kreij, Nicole A Datson, Willeke MC van Roon-Mom, Annemieke Aartsma-Rus, Onno C Meijer

Abstract

Antisense oligonucleotide (AON)-mediated exon skipping is a powerful tool to manipulate gene expression. In the present study we investigated the potential of exon skipping by local injection in the central nucleus of the amygdala (CeA) of the mouse brain. As proof of principle we targeted the splicing of steroid receptor coactivator-1 (SRC-1), a protein involved in nuclear receptor function. This nuclear receptor coregulator exists in two splice variants (SRC-1a and SRC-1e) which display differential distribution and opposing activities in the brain, and whose mRNAs differ in a single SRC-1e specific exon.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 3%
Unknown 32 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 36%
Student > Master 5 15%
Student > Ph. D. Student 5 15%
Other 4 12%
Librarian 3 9%
Other 2 6%
Unknown 2 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 42%
Neuroscience 7 21%
Biochemistry, Genetics and Molecular Biology 2 6%
Computer Science 2 6%
Medicine and Dentistry 2 6%
Other 5 15%
Unknown 1 3%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 January 2013.
All research outputs
#20,178,031
of 22,691,736 outputs
Outputs from BMC Neuroscience
#1,051
of 1,240 outputs
Outputs of similar age
#249,425
of 281,525 outputs
Outputs of similar age from BMC Neuroscience
#19
of 32 outputs
Altmetric has tracked 22,691,736 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,240 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,525 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.